ForecastOne API Portal Login

ForecastOne® API for ALS Clinical Trials

On-demand patient-level disease progression predictions delivered through a secure, cloud-based REST API that brings virtual patients directly to your system.

ForecastOne API Client Portal

Seamless ALS progression insights

ForecastOne API provides sponsors, CROs, and industry partners with real-time access to ALS disease progression forecasts from baseline clinical data. Designed to interface with EDC platforms and analytics workflows, the API returns structured predictions through secure HTTPS calls using de-identified patient data. Users can integrate these virtual patients into their EDC/data pipeline for analysis, stratification, and trial planning.

High-fidelity predictions

Access validated machine learning models for ALSFRS-R, respiratory outcomes, survival and other time-to-event endpoints.

Effortless integration

JSON inputs/outputs fit directly into your systems—no extra data entry, no delays, and consistent schemas across models.

Secure & compliant

Built for controlled access, encryption in transit, and quality-system-aligned operational practices with auditability.

How it works
  • Submit de-identified patient visit data via secure HTTPS request
  • API returns structured predictions across multiple ALS outcomes

Available prediction categories

ForecastOne provides access to a validated ALS model library spanning functional outcomes and time-to-event endpoints.

Functional endpoints
  • ALSFRS-R Total
  • ALSFRS-R subscores (Chest, Face, Fine Motor, Gross Motor)
Respiratory endpoints
  • % Vital Capacity and related respiratory measures
  • Event-based respiratory endpoints (e.g., VC50)
Survival & time-to-event endpoints
  • Time to Death (and tracheostomy-free survival configurations)
  • PEG, Speech Loss, Wheelchair Use
Model details

Full required-fields matrices, payload formats, and model-specific details are in the Client Portal documentation.

How teams use ForecastOne in ALS trials

Origent’s predictive models can be applied across the trial lifecycle to make ALS clinical trials smaller, faster, and more likely to succeed.

Digital Twins & Virtual Controls
Create patient-level forecasts to enable virtual control arms or prognostic matching when placebo arms are limited.

Stratification & Randomization
Stratify patients by predicted progression (e.g., fast vs slow) to optimize randomization and increase power.

Covariate Adjustments
Include individualized predictions as covariates to reduce variance and boost ability to detect treatment effect.

Subgroup Analysis
Identify subgroups where treatment effects are most likely to be observed to inform analysis and future study design.

Get started in three steps

1) Subscribe
We’ll provision portal access and API keys for your team.

2) Build & test
Use the docs, code examples, and Try Me tool to validate payloads and troubleshoot before going live.

3) Deploy
Generate predictions in your workflows and store results in your database for downstream trial analyses and reporting.

Security & compliance

ForecastOne is designed for secure clinical integrations and quality-system-aligned operations.

Security and compliance icons

FAQ

Who is this for?

ForecastOne is built for drug sponsors, CROs, academic researchers, digital health partners, and analytics platforms conducting clinical trials and research for candidate drug programs.

Is PHI transmitted?

No. The API is intended for de-identified patient data only; no PHI is transmitted.

How do we validate our integration?

Use the Client Portal Online Testing Tool and code examples to validate payloads and troubleshoot errors before going live.

How do we get access?

ForecastOne API Client Portal

The Client Portal offers a full suite of tools to support client integration and usage monitoring:
API Documentation
Left-nav documentation with Swagger UI and clear implementation guidance.

Code Examples
Copy/paste examples in cURL, Python, and JavaScript to speed integration.

Online Testing Tool
Validate payload structure and troubleshoot errors with a guided test tool.

Usage Dashboards
Monitor calls over time, filter by status and billing class, export CSV.

API documentation for implementation teams

Explore endpoints, required inputs, and response schemas with interactive Swagger UI and production-ready examples.

ForecastOne API Docs screenshot

Usage dashboards for monitoring & reporting

Track volume and performance, filter by date range and status, and export tables for reconciliation.

ForecastOne API Dashboard screenshot

Ready to bring virtual patients into your system?

Log in to view the API documentation and dashboards, or subscribe to the service.