Managing Drug Development Risks through Better Foresight
The Industry Challenge: Rising Costs, Delayed Insights, and Patient Disconnect
The cost of bringing new therapies to market has skyrocketed—from $100 million in 1975 to over $5 billion today. A primary contributor to this inflation is the soaring expense of human clinical trials, which now consume nearly two-thirds of pharmaceutical R&D budgets. Trials are longer, more complex, and increasingly labor-intensive—placing pressure on researchers to show results earlier, and discouraging investment in rare or complex diseases.
Yet the industry faces another, deeper challenge: the most critical delays don’t just occur in the lab or during trials—they begin long before diagnosis. In a fragmented, clinician-centered system, patients struggle to articulate their symptoms, contextualize their experiences, and access appropriate care. These early blind spots not only delay treatment, but also suppress the patient voice—the richest, yet most underutilized dataset in medicine.
Our Evolution: From Predictive Precision to Patient Empowerment
Origent was founded on the belief that better foresight drives better outcomes. For over a decade, we’ve specialized in predictive modeling for ALS, helping biopharma sponsors, CROs, and academic researchers reduce clinical trial risk through patient-level forecasting. Our models—built on individual trajectories, not just population averages—have helped optimize trial design, shorten timelines, and unlock therapeutic insights in one of medicine’s most complex domains.
As our work deepened, one truth became clear: the most critical variables in health outcomes often surface before clinical trials even begin. Symptoms, context, and lived experience—too often missing from traditional datasets—hold the key to earlier intervention, smarter care, and more inclusive innovation.
That insight drives our evolution. We’re building on our predictive modeling foundation to empower patients directly—capturing the data that precedes diagnosis, and turning narrative into structured, actionable intelligence.
Introducing Origent AI Companion: The Next Generation of Health Intelligence
Origent’s AI companion is a narrative health platform that transforms unstructured patient stories into structured, actionable data. It captures what the healthcare system misses—symptoms, emotions, lifestyle, and lived experience—and empowers patients to navigate their care with clarity and confidence.
This new data class bridges the gap between electronic records and real-life realities, improving early signal detection, accelerating diagnosis, and driving equity-centered insights. For life sciences, Origent’s AI companion unlocks opportunities for:
- Smaller, smarter trials through earlier identification of patient subgroups
- Richer real-world evidence derived directly from patient narratives
- Stronger investor confidence enabled by continuous, personalized insights
- Greater market access through engagement with underserved or undiagnosed populations
Why Origent?
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