Presented at the 26th International Symposium on Amyotrophic Lateral Sclerosis and Motor Neurone Disease, Orlando Florida, December 2015.
This poster used random forests and gradient boosting machine algorithms to develop individual patient-level disease progression predictions for ALS patients involved in a clinical trial of the NeuRx DPS® Diaphragm Pacing System (DPS). Virtual controls for ALSFRS-R and survival were generated from the predictions and compared to the observed outcomes.
Citation: Taylor A, Miller R, Onders R and Ennist D. Analysis of function and survival in ALS patients with diaphragm pacing using virtual controls [v1; not peer reviewed]. F1000Research 2016, 5:120 (poster) (doi:10.7490/f1000research.1111282.1)
Published online at F1000Research.com, on January 29, 2016.